Hepatic Failure

From WikiLectures

  • Acute liver failure - life-threatening failure of liver functions (synthetic, biotransformation) occurring within 8 weeks of the first symptoms, the main feature being hepatic encephalopathy.
  • Chronic liver failure - gradual development of symptoms.

Causes[edit | edit source]

The most common causes of acute failure:

  1. viral hepatitis (so-called fulminant) – especially VHA, VHB;
  2. intoxication with drugs (paracetamol, halothane) or toxic substances (mushroom poisoning, drugs – ecstasy);
  3. metabolic disorders (Wilson's disease, Reye's syndrome);
  4. venostasis (acute Budd-Chiari syndrome, shock, P failure).

The cause is massive necrosis of hepatocytes.

The cause of chronic liver failure is liver cirrhosis (most often alcoholic), liver tumors and liver metastases


Clinical Manifestations[edit | edit source]

Diagnostics[edit | edit source]

Treatment[edit | edit source]

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