Gonosomal recessive inheritance

An example of a family tree with a gonosomally recessive trait

Gonosomal recessive inheritance is the transmission of the observed trait, the allele oh which lies gonosome, namely chromosome X (X-linked inheritance). Few genes are located on the chromosome Y, eg. SRY. The increased pubic hair previously reported as an example of a Y-linked trait (OMIM: 425500), is probably not strongly linked to the Y chromosome.

A typical manifestation is a far greater number of sick men than women, who are overwhelmingly only healthy carriers.

Deviations

Some inconsistencies may arise because carriers have different degrees of disease manifestation. It is caused by random lyonization of one of the X chromosomes in each cell of the body. This can occur, for example, in hemophilia.

Examples

Monogenically inherited diseases
autosomally inherited diseases autosomal dominant inheritance autosomal inherited agammaglobulinemia • achondroplasia • Apert syndrome • brachydactyly • familial hypercholesterolemia • Huntington's chorea • Marfan syndrome • myotonic dystrophy • neurofibromatosis • osteogenesis imperfecta (late form) • polycystic kidney disease • polydactyly • Thomsen syndrome
autosomal recessive inheritance autosomal inherited agammaglobulinemia • Ataxia telangiectasia • cystic fibrosis • phenylketonuria • Friedreich's ataxia • osteogenesis imperfecta (early form) • polycystic kidney disease • galactosemia • glycogenoses • congenital adrenal hyperplasia • sickle cell anemia • Hurler syndrome • Tay-Sachs disease • Thomsen syndrome • thalassemia • Werdnig-Hoffmann disease • Wilson disease
gonosomally inherited diseases gonosomal dominant inheritance incontinentia pigmenti • vitamin D-resistant rickets
gonosomal recessive inheritance Becker muscular dystrophy • Bruton's agammaglobulinemia • color blindness • Duchenne muscular dystrophy • hemophilia A • hemophilia B • Wiskott-Aldrich syndrome
Y-linked inheritance --