Autosomal dominant inheritance

From WikiLectures

An example of a family tree with an autosomal dominantly inherited trait

Basic characteristics[edit | edit source]

  • refers to genes located on non-sex chromosomes – autosomes
  • we observe the transmission of a trait at a conditional dominant by an allele
  • phenotypicwise, the monitored trait is manifested both in heterozygotes (Aa) and in dominant homozygotes ( AA)
  • in the case of incomplete dominance, heterozygotes (Aa) have less severe phenotypic manifestations than dominant homozygotes (AA), in which the respective disease manifests itself in a very severe form
  • phenotypically healthy individuals (recessive homozygotes) do not transmit the mutation to subsequent generations

Genealogical characteristics[edit | edit source]

Searchtool right.svg For more information see Genealogy.
  • 'both sexes are affected equally often
  • typically it is vertical type of inheritance - at least one parent is affected (most often heterozygous), the disease occurs in practically every generation

Risk calculation[edit | edit source]

  • when two heterozygotes (Aa) are crossed, there is a three-quarters probability (75%) of the birth of an affected offspring (in 25% of cases, the affected individual is a dominant homozygous AA)
A a
a Aa aa
  • when a recessive homozygote (aa) is crossed with a heterozygote (Aa) there is a half (50%') probability of the birth of an affected offspring (Aa)
a a
A Aa Aa
a aa aa

Deviations[edit | edit source]

Examples[edit | edit source]


Links[edit | edit source]

related articles[edit | edit source]

Exercising[edit | edit source]

Reference[edit | edit source]

  1. ADAMČOVÁ, Hana. Neurology 2005. Trendy v medicíně edition. Triton, 2005. 260 pp. ISBN 80-7254-613-9.

References[edit | edit source]

  • THOMPSON, James Scott – THOMPSON, Margaret Wilson – NUSSBAUM, Robert L. Clinical genetics: Thompson & Thompson. 6. edition. Triton, 2004. 426 pp. ISBN 80-7254-475-6.