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Infection of a cell by Ehrlichia. 1: bacteria entering the cell. 2, 3, 4: reproduction and Morula in the cytoplasm of a neutrophil

Ehrlichiosis or anaplasmosis is anthropozoonosis caused by obligatory intracellular bacteria and transmitted by ticks.

  • it is a newly diagnosed disease - previously thought to be infectious to dogs only
  • may resemble some forms of Lyme borreliosis
  • occurs very rarely in the Czech Republic [1]

Etiology[edit | edit source]

  • gram-negative bacteria of the genus Ehrlichia, in our country Anaplasma (formerly Ehrlichia) phagocytophila
  • transmission tick (genus Ixodes, Amblyoma, Dermacentor)
  • the morphology of bacteria is variable, usually cocci or cocobacillus
  • Intracytoplasmic vacuolar microcolonies of Ehrlichia chaffeensis in leukocytes
    is located inside leukocytes in membrane-bounded vacuoles, forming intracytoplasmic vacuolar microcolonies called "morulas"[2]

Pathogenesis[edit | edit source]

Bacteria penetrate:

  1. granulocytes - the so-called human granulocyte ehrlichiosis / anaplasmosis - HGE, IGA - originates of the Anaplasma phagocytophilum, transmitted by ticks of the genus Ixodes, the reservoir is small mammals, wild animals and horses; co-infection possible Borrelia burgdorferi
  2. monocytes - human monocytic ehrlichiosis / anaplasmosis is formed - HME, IME - causative agent E. chaffeensis, transmitted by ticks of the genera Amblyoma and Dermacentor, the reservoir is dogs and wild animals[2]

Clinical picture[edit | edit source]

Diagnostics[edit | edit source]

Therapy[edit | edit source]

Sources[edit | edit source]

Literature[edit | edit source]

  • HAVLÍK, Jiří. Infektologie. 2. edition. 1990. ISBN 80-201-0062-8.
  • LOBOVSKÁ, Alena. Infekční nemoci. 1. edition. 2001. ISBN 80-246-0116-8.

References[edit | edit source]

  1. a b BENEŠ, Jiří. Studijní materiály [online]. [cit. 2009]. <>.
  2. a b c d BARTŮNĚK, P. Lymeská borelióza [online] 3. edition. 2006. pp. 116. Available from <>.