Dysostosis cleidocranialis

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Dysostosis (dysplasia) cleidocranialis is an AD hereditarydisorder of desmogenous (gum, calf, pelvis) and enchondral (arm, leg, spine) ossification. For example, actor Gaten Matarazzo (who played Dustin Henderson in Stranger Things) suffers from the disease.

Pathogenesis[edit | edit source]

  • Mutation of the RUNX2 gene (runt related transcription factor 2, gene naming recommended by HGNC; former gene name CBFA1) → abnormal bone tissue produced.[1]

Clinical picture[edit | edit source]

It usually manifests itself in the first 2 years, typical symptoms are:

  • broad head, relatively small face with hypertelorism, vertical shoulders, narrow chest, dentition disorder, persistent fontanelles,
  • aplasia / hypoplasia of the clavicle,
  • short stature
  • hypermobility of the arm girdle,
  • neuromuscular disorders from brachial plexus damage and agenesis of some chest muscles,
  • scoliosis, hollow chest,
  • brachycephaly,
  • poorly developed dentition (delayed eruption and replacement of teeth).

X-ray image[edit | edit source]

  • Defective clavicles(in the lateral and central part),
  • delayed closrie of fontanelles and cranial sutures (as opposed to craniostenosis),
  • possibly deformities of the chest, pelvis, scoliosis, spina bifida occulta.

Therapy[edit | edit source]

  • Reconstruction of the clavicles is not recommended, sometimes decompression of the brachial plexus,
  • coxa vara: valgus intertrochanteric osteotomy,
  • strengthening of the muscles of the shoulder girdle: exercise, bandage,
  • treatment of scoliosis.


Links[edit | edit source]

Related articles[edit | edit source]

Reference[edit | edit source]

  1. MENDOZA-LONDONO, Roberto and Brendan LEE. Cleidocranial Dysplasia  [online]. [feeling. 2017-05-29]. < https://www.ncbi.nlm.nih.gov/books/NBK1513/ >.
  2. WANG, Jiangping, Xinwen HUANG, and Can LAI, et al. Clinical spectrum of cleidocranial dysplasia in a family with twins. Pediatr Int [online] . 2013, vol. 55, no. 3, pp. 392-5, also available from < https://www.ncbi.nlm.nih.gov/pubmed/23782374 >. ISSN 1442-200X. 

Sources[edit | edit source]

  • DUNGLE, P., et al. Orthopedics. 1st edition. Prague: Grada Publishing, 2005.  ISBN 80-247-0550-8 .
  1. MENDOZA-LONDONO, Roberto – LEE, Brendan. Cleidocranial Dysplasia [online]. [cit. 2017-05-29]. <https://www.ncbi.nlm.nih.gov/books/NBK1513/>.