Hyaline petrification
From WikiLectures
Intracellular occurrence of hyaline in the form of deposits or droplets, examples:
- Mallory hyalin – cytokeratin coiled into a ball in the cytoplasm of hepatocytes in alcoholic cirrhosis
- Councilman's bodies - apoptotic bodies in hepatocytes in hepatitis , tend to be inside the ER (as well as inclusions of α 1 -antitrypsin deficiency ).
- Crooke's cells – non-cancerous cells in the vicinity of a pituitary adenoma producing ACTH (thus causing Cushing's disease ). They contain spirally coiled cytokeratins in the cytoplasm.
- Russell bodies – inclusions in the cytoplasm of plasma cells during chronic inflammation (correspond to Ig accumulated in GER). The cell acquires a silky appearance, when it ruptures, the hyaline gets into the extracellular space.
- Trachoma bodies – in the cytoplasm of the conjunctival epithelium during Chlamydia trachomatis infection , they contain glycogen.
- Viral inclusions - they are formed either by own viral inclusions or by proteins of cells damaged by the virus, they can be:
- intranuclear – e.g. in keratinocytes in herpes infections;
- intracytoplasmic – e.g. in ganglion cells in rabies (so-called Negri bodies ).
- Dystrophic changes of ganglion cells – in degenerative brain diseases, e.g. Lewy bodies (spherical eosinophilic inclusions in the cytoplasm of ganglion cells, there is a clearing around them, they are larger than the nucleus).
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Source[edit | edit source]
- PASTOR, Jan. Langenbeck's medical web page [online]. ©2006. [cit. 2011-10-22]. <https://langenbeck.webs.com/>.
