Diseases caused by increased number of erythrocytes

From WikiLectures

Under construction / Forgotten

This article was marked by its author as Under construction, but the last edit is older than 30 days. If you want to edit this page, please try to contact its author first (you fill find him in the history). Watch the discussion as well. If the author will not continue in work, remove the template {{Under construction}} and edit the page.

Last update: Thursday, 12 Nov 2020 at 4.46 pm.

Polycythaemia vera

[edit part] Polycythaemia vera

Secondary polyglobulia

[edit part] Secondary polyglobulia is mostly compensatory in chronic hypoxia (leads to ↑ EPO) when staying at high altitude, chronic lung disease, right-to-left shunts, methemoglobinaemia.

Less often, the cause of ↑ EPO is unclear/a manifestation of a disease (kidney tumors, uterine myomatosis, polycystic kidney disease, etc.).

The clinical picture

Laboratory Tests

  • ↑ erythrocytes, HTK > 48%, oxygen saturation <92%, ↑ EPO (dif. dg. Polycytaemia vera).


  • Th. of underlying disease, venipuncture (↓ blood viscosity + reduces the risk of complications).[1]


[edit part]

False polyglobulia is caused by a decrease in volume of plasma, total erythrocyte volume is normal:

Neonatal polycythemia

Neonatal polycythemia is defined as a central venous hematocrit > 0,65. Nowever, even with a hematocrit> 0.70, only a small proportion of neonates have clinical signs of hyperviscosity. The clinical picture includes lethargy, hypotension, hyperbilirubinemia and hypoglycemia. Polycythemia may also be involved in the development of convulsions, stroke, renal venous thrombosis and necrotizing eneterocolitis.

Causes of neonatal polycythemia:

Treatment is controversial and may not be necessary in neonates with mild symptoms (eg borderline glycaemia, impaired peripheral blood flow). Treatment is indicated in neonates with a hematocrit> 0.65 and symptoms with a potentially severe prognosis (eg refractory hypoglycaemia, neurological symptoms). A partial exchange transfusion is performed with a crystalloid solution (eg physiological solution) with a target hematocrit of 0.55.[2]

Searchtool right.svg For more information see Polycythemia (neonatology).


Related articles


  1. KLENER, P. Vnitřní lékařství. 3. edition. Galén, 2006. ISBN 80-7262-430-X.
  2. LEDVINA, Miroslav, et al. Biochemie pro studující medicíny. 2. vydání. Praha : Karolinum, 2009. 548 s. s. 85-90. ISBN 978-80-246-1414-4.

Template:Navbox - onemocnění krve

Kategorie:Vnitřní lékařství Kategorie:Hematologie