Diseases caused by increased number of erythrocytes

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Last update: Thursday, 12 Nov 2020 at 4.46 pm.


Polycythaemia vera

[edit part] Polycythaemia vera

Secondary polyglobulia

[edit part] Secondary polyglobulia is mostly compensatory in chronic hypoxia (leads to ↑ EPO) when staying at high altitude, chronic lung disease, right-to-left shunts, methemoglobinaemia.

Less often, the cause of ↑ EPO is unclear/a manifestation of a disease (kidney tumors, uterine myomatosis, polycystic kidney disease, etc.).

The clinical picture

Laboratory Tests

  • ↑ erythrocytes, HTK > 48%, oxygen saturation <92%, ↑ EPO (dif. dg. Polycytaemia vera).

Therapy

  • Th. of underlying disease, venipuncture (↓ blood viscosity + reduces the risk of complications).[1]

Erythrocytosis

[edit part]

False polyglobulia is caused by a decrease in volume of plasma, total erythrocyte volume is normal:

Neonatal polycythemia

Neonatal polycythemia is defined as a central venous hematocrit > 0,65. Nowever, even with a hematocrit> 0.70, only a small proportion of neonates have clinical signs of hyperviscosity. The clinical picture includes lethargy, hypotension, hyperbilirubinemia and hypoglycemia. Polycythemia may also be involved in the development of convulsions, stroke, renal venous thrombosis and necrotizing eneterocolitis.

Causes of neonatal polycythemia:


Treatment is controversial and may not be necessary in neonates with mild symptoms (eg borderline glycaemia, impaired peripheral blood flow). Treatment is indicated in neonates with a hematocrit> 0.65 and symptoms with a potentially severe prognosis (eg refractory hypoglycaemia, neurological symptoms). A partial exchange transfusion is performed with a crystalloid solution (eg physiological solution) with a target hematocrit of 0.55.[2]

Searchtool right.svg For more information see Polycythemia (neonatology).


Links

Related articles

Reference

  1. KLENER, P. Vnitřní lékařství. 3. edition. Galén, 2006. ISBN 80-7262-430-X.

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Kategorie:Vnitřní lékařství Kategorie:Hematologie