Systemic treatment in dermatology

Systemic treatment in dermatology does not differ from the application of drugs in other fields. We use ATB, chemotherapeutics, cytostatics, immunosuppressants, venotonics, antihistamines, anticoagulants, vasodilators, vitamins, sedatives etc.

Systemic use of corticoids

Corticosteroids have a morbidistatic suppressing the symptoms and development of the disease without curing it), anti- allergic and anti-inflammatory effect.

Long-term side effects

Formation or perforation of a GIT ulcer, hypertension, block of ACTH secretion, mineral disorders, osteoporosis, Cushing's syndrome, acneiform rashes, hypertrichosis, stretch marks, steroid diabetes, depressive psychoses, thrombosis, activation of latent infections,...

Indication

Severe or inauspicious dermatoses – prolongs life, alleviates suffering, pemphigus, acute erythematodes, generalized scleroderma;
severe and extensive chronic or recurrent ermatoses – relief or induces a healing phase, erythroderma, extensive eczema, psoriasis, lichen planus;
severe acute dermatoses – they disappear over time, but shock corticoids dampen, acute allergic reactions (Quincke's edema, urticaria, serum sickness), Stevens-Johnson syndrome, erythema nodosum.

Dosage

It is individual:

shock, initial doses – 5-20 tablets (20-100mg) per day of Prednisone, Triamcinolone or Dexamethasone, most in the morning, least in the evening;
maintenance 1−2 tbl.

Contraindication

ulcer disease, DM, hypertension, coronary insuff., IM, TBC, pregnancy;
need to monitor urine, minerals, weight, BP.

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