Ferritin
"Ferritin" is a storage protein containing iron, which is found mainly in the liver, spleen, bone marrow and intestinal mucosa. A small proportion is released into the bloodstream. The level of ferritin in the blood serum reflects the tissue stores of iron. Its value decreases before the level of transferrin u increases. [1]
It is a complex consisting of the protein apoferritin em and the ferric iron Fe 3+ . [2]
Normal values of ferritin
- Males: 22 - 322 μg / l
- Women: 10 - 291 μg / l [3]
High Iron level
- Hemochromatosis,
- Wilson's disease,
- Blood transfusion,
- Excessive iron intake in the diet,
- Porphyria cutanea tarda,
- Ineffective erythropoiesis (sideroblastic anemia, thalassemia).
Inflammation
Ferritin is one of the acute phase reactants
- Rheumatoid arthritis,
- SLE,
- non-specific intestinal inflammation,
- bacterial infections;
Liver disease
Ferritin is stored mainly in hepatocytes, when they are damaged it is released into the blood.
- liver steatosis (NASH),
- viral hepatitis B, C;
Other causes
Obesity, alcohol abuse, thyrotoxicosis and malignancies, especially haematological [4] Rarely, extremely high levels of ferritin can be a symptom of histiocytosis or Still's disease. [5]
Links
External links
References
- ↑ SEAGULL, J, et al. Clinical Biochemistry. 1. edition. Prague : Galén - Karolinum, 1999. pp. 64. ISBN 80-7262-023-1.
- ↑ ŠVÍGLEROVÁ, Jitka. Ferritin [online]. The last revision 2009-02-18, [cit. 2010-11-13]. <https: //web.archive.org/web/20160416225121/http: //wiki.lfp-studium.cz/index.php/Feritin>.
- ↑ VOKURKA, Martin. Great Medical Dictionary. 10. edition. Maxdorf, 2015. ISBN 9788073454562.
- ↑ BERKHAN, L. Interpretation of an elevated serum ferritin. nzfp [online]. 2002, vol. 29, p. 45-48, Available from <http://www.rnzcgp.org.nz/AsiCommon/Controls/Shared/FormsAuthentication/Login.aspx?ReturnUrl=%2fassets%2fdocuments%2fPublications%2fArchive-NZFP%2fFeb-2002-NZFP-Vol-29-No -1% 2fberkhan.pdf>.
- ↑ ADAMS, Paul. Management of Elevated Serum Ferritin Levels. Gastroenterology and hepatology [online]. -, vol. -, p. 333-334, Available from <https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC3093720/>.
