Eradication of Helicobacter pylori
Basic Therapy[edit | edit source]
The treatment regimen used for Helicobacter pylori eradication therapy includes a basic three-drug combination. Treatment in the Czech Republic takes 10-14 days.
| Combination of preparations (10-14 days) | Dose | |
|---|---|---|
| omeprazole, lansoprazole, pantoprazole, esomeprazole, rabeprazole | 2 x 20 mg, 2 x 30 mg, 2 x 40 mg, 2 x 40 mg,2 x 20 mg | |
| clarithromycin, (metronidazole) | 2 x 500 mg, 2 x 500 mg | |
| amoxicillin | 2 x 1000 mg |
The combination used in case of ""allergy"" to penicillin antibiotics:
| Combination of preparations (10-14 days) | Dose | |
|---|---|---|
| omeprazole, lansoprazole, pantoprazole, esomeprazole, rabeprazole | 2 x 20 mg, 2 x 30 mg, 2 x 40 mg, 2 x 40 mg,2 x 20 mg | |
| clarithromycin, azithromycin | 2 x 500 mg, 1 x 500 mg 5 days | |
| metronidazole, tinidazole | 2 x 400-500 mg, 2 x 400-500 mg |
With this combination treatment, eradication can be achieved in 90%. In case of recurrent infection, we administer a four combination': (not available in the Czech Republic)
| Combination of preparations (7 days) | Dose | |
|---|---|---|
| omeprazole, lansoprazole, pantoprazole, esomeprazole, rabeprazole | 2 x 20 mg, 2 x 30 mg, 2 x 40 mg, 2 x 40 mg,2 x 20 mg | |
| colloidal bismuth | 4 × 120 mg | |
| tetracycline, amoxycillin | 4 x 500 mg, 2 x 1000 mg | |
| metronidazole | 2–3 × 500 mg |
In case of recurrent infections, 'sequential treatment can also be administered. This consists of administering an IPP twice a day + levofloxacin 2x 500 mg or amoxicillin 2x 1000 mg for the first five days and then a combination of an IPP twice a day with clarithromycin and metronidazole for the next five days.
HVLP Examples[edit | edit source]
Assignment: Prescribe a preparation used in the eradication of Helicobacter pylori: amoxicillin + ranitidine complex with bismuth citrate.
Rp.
AMOCLEN 30 × 500 cps.
Exp. orig. No. II (duas)
D. S. 1 tablet after 6 hours
ERADIPAK 14 × 40 mg tablet. obd.
Exp. orig. No. I (unam)
D. S. 1 tablet twice a day.
Links[edit | edit source]
References[edit | edit source]
- VONDRÁČKOVÁ, Hana. Magisterial recipe [lecture on the subject of Pharmacology, branch of Dentistry, 1st Faculty of Medicine, UK]. Prague.
- PHARMINDEX breviary
- {{#switch: book
|book =
Incomplete publication citation. CZECH, Richard, et al. Intern. Prague : Triton, 2015. 909 s. 978-80-7262-438-6.
|collection =
Incomplete citation of contribution in proceedings. CZECH, Richard, et al. Intern. Prague : Triton, 2015. 909 s. {{
#if: 978-80-7387-895-5 |978-80-7262-438-6} }
|article =
Incomplete article citation. CZECH, Richard, et al. 2015, year 2015,
|web =
Incomplete site citation. CZECH, Richard, et al. Triton, ©2015.
|cd =
Incomplete carrier citation. CZECH, Richard, et al. Triton, ©2015.
|db =
Incomplete database citation. Triton, ©2015.
|corporate_literature =
CZECH, Richard, et al. Intern. Prague : Triton, 2015. 909 s. 978-80-7262-438-6} }
- MDr. TOMISLAV ŠVESTKA, CSC,. Helicobacter pylori infection. Medicine for practice [online]. 2011, no. 3, pp. 123-126, also available from <https://www.medicinapropraxi.cz/pdfs/med/2011/03/06.pdf>.
Links[edit | edit source]
Helicobacter pylori infection – recommended procedure
