Antithrombotics

Antithrombotic mechanisms:

Heparin

Antithrombotics are substances that reduce blood clotting.

1. Anticoagulants - reduce blood clotting by affecting the production and effects of coagulation factors.
   • Direct - heparin and low molecular weight heparins - act as catalytic cofactors of antithrombin III and inhibit some serine proteases coagulation cascades.
   • Indirect - oral anticoagulants (coumarol derivatives - warfarin, pelentan) - inhibit the functions of vitamin K.
2. Antiplatelet agents – prevent the formation of a thrombus by inhibiting the functions of platelets – e.g. acetylsalicylic acid.
3. Thrombolytics – dissolve the formed thrombus, include fibrinolytics – e.g. streptokinase.

Warfarin

Links

Related Articles

• Hemostasis
• Anticoagulants
• Thrombolytics
• Hemocoagulation

Source

• PASTOR, Jan. Langenbeck's medical web page [online]. ©2006. [cit. 2011-10-22]. <https://langenbeck.webs.com/>.

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