Acquired coagulopathy
Acquired defects of factors II, V, VII, IX and X
Acquired defects of factors II, V, VII, IX and X arise in advanced liver diseases, [vitamin K]] deficiency/inhibition.
- Absorption disorder of vit. K: obstructive jaundice, malabsorption syndrome (pancreatic / intestinal origin),
- coumarin preparations act as inhibitors of vit. K (warfarin, see figure),
- in liver diseases, the production of f. II, VII, IX, X, V decreases gradually; u go ahead conditions complex disorder of hemostasis + in addition thrombocytopenia (with splenomegaly), increased fibrinolytic activity (portocaval anastomoses + ↓ detoxification capabilities of the liver),
- in liver diseases, hemorrhagic conditions of varying severity, threat to hl. bleeding into the GIT.
Therapy
- Lack of vit. K / overdose of coumarin → administration of vit. K (Kanavit),
- at hep. replacement disease: K-plasma, prothrombin complex concentrates, fresh frozen plasma,
- antifibrinolytics + glucocorticoids.
Links
References
- KLENER, Pavel, et al. Vnitřní lékařství. 3. edition. 2006. ISBN 80-7262-430-X.
Related articles
- Cirkulující antikoagulancia WikiSkripta. Cirkulující antikoagulancia - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Cirkuluj%C3%ADc%C3%AD_antikoagulancia>.
- Poruchy hemostázy WikiSkripta. Poruchy hemostázy - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Poruchy_hemost%C3%A1zy>.
Acquired defects of factors II, V, VII, IX and X arise in advanced liver diseases, [vitamin K]] deficiency/inhibition.
- Absorption disorder of vit. K: obstructive jaundice, malabsorption syndrome (pancreatic / intestinal origin),
- coumarin preparations act as inhibitors of vit. K (warfarin, see figure),
- in liver diseases, the production of f. II, VII, IX, X, V decreases gradually; u go ahead conditions complex disorder of hemostasis + in addition thrombocytopenia (with splenomegaly), increased fibrinolytic activity (portocaval anastomoses + ↓ detoxification capabilities of the liver),
- in liver diseases, hemorrhagic conditions of varying severity, threat to hl. bleeding into the GIT.
Therapy
- Lack of vit. K / overdose of coumarin → administration of vit. K (Kanavit),
- at hep. replacement disease: K-plasma, prothrombin complex concentrates, fresh frozen plasma,
- antifibrinolytics + glucocorticoids.
Circulating anticoagulants
Circulating anticoagulants are agents with an anticoagulant effect; they appear in the blood under pathological circumstances.
- (Allo-/auto)antibodies against coagulation factor (hl. against f. VIII);
- antiphospholipid antibodies (eg. in SLE, antiphospholipid syndrome);
- fibrin/fibrinogen cleavage products during activated fibrinolysis;
- pathologically produced substances of a heparin nature;
- paraprotein in monoclonal gammopathy;
Source
References
- KLENER, P. – ET AL.,. Vnitřní lékařství. 3. edition. 2006. ISBN 80-7262-430-X.
Related Articles
- Poruchy hemostázy WikiSkripta. Poruchy hemostázy - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Poruchy_hemost%C3%A1zy>.
- Warfarin WikiSkripta. Warfarin - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Warfarin>.
- Antikoagulancia WikiSkripta. Antikoagulancia - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Antikoagulancia>.
