Antifibrinolytics
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- block the binding of plasmin to fibrin
Indication
- during dental procedures in hemophiliacs
- during bleeding after surgical interventions (after tonsillectomy) - when replacing coagulation factors
Contraindications
- in the presence of intravascular coagulation
Side effects
- vomiting
Principal Representatives
- Aminocaproic acid
- per os or intravenously (administer slowly - this will prevent the possible development of shock and intravascular thrombosis)
- reduces the activation of plasminogen
- Tranexamic acid
- the same administration as for aminocaproic acid, but it has a significantly longer effect
- Aprotinin
- used for bleeding in fibrinolysis disorders, or in the treatment of pancreatitis
- p-aminomethylbenzoic acid (PAMBA)
Links
Related Articles
Source
- LINCOVÁ, Dagmar – FARGHALI, Hassan. Základní a aplikovaná farmakologie. 2. edition. Galen, 2007. 672 pp. ISBN 978-80-7262-373-0.
