Thrombocytopenia from reduced platelet production
From WikiLectures
These are mostly amegakaryocytic thrombocytopenia , which means that there is a reduced amount of megakaryocytes in the bone marrow or megakaryocytes are completely absent. In this case, the attenuation is isolated / more often in the attenuation of the entire myeloid line;
- More often acquired – treatment with myelotoxic substances + ionizing radiation, viral infections, infiltration of the bone marrow by malignancy, remodeling in myeloproliferative diseases , in idiopathic ones the involvement of immunological mechanisms is assumed .
Megakaryocytic thrombocytopenia – in the bone marrow a normal / increased number of megakaryocytes with shape deviations
- Thrombocytopenia in megaloblastic anemia , PNH , MDS , etc.,
- Rare hereditary thrombocytopenic thrombocytopathies (eg Bernard-Soulier syndrome).
Diagnostics[edit | edit source]
- Bone marrow examination – reduction or absence of megakaryocytes,
- Severe prognosis (hemorrhage into the CNS),
- Symptoms from the involvement of other components of hematopoiesis may prevail.
Therapy[edit | edit source]
- Secondary thrombocytopenia – treatment of the primary disease process, removal of the causative agent,
- Immunosuppressive treatment (some cases),
- Allogeneic bone marrow transplantation ,
- Symptomatic therapy: glucocorticoids , fibrinolysis inhibitors (PAMBA), platelet transfusion (to ensure surgery).
Links[edit | edit source]
References[edit | edit source]
- KLENER, P. Vnitřní lékařství. 3. edition. Praha : Galén, 2006. ISBN 80-7262-430-X.
