Polyarteritis nodosa

From WikiLectures

Polyarteritis nodosa (polyarteritis, clasic polyarteritis nodosa, PAN) is an inflammatory disease of small and medium vessels of the skin, kidneys, peripheral nerves, cardiovascular and gastrointestinal systems. It affects the entire wall of the vessel and carries a lot of complications (aneurysm, thrombus, infarction and even manifestations of multi-organ failure).

Epidemiology and etiology[edit | edit source]

It is a rare disease, more often affecting men around 50 years of age. The etiology is not yet clear, immune-complexes and some viruses are being considered (HBV, CMV, HIV, parvoviruses).

Clinical symptoms[edit | edit source]

The disease is accompanied by general signs of inflammation and varying severity of organ system damage.

Diagnosis[edit | edit source]

  • Patient history.
  • Physical exam.
  • Laboratory examination methods: ↑ FW + CRP, eosinophilia, 1/3 of patients HbsAg+, c-ANCA+.
  • Angiography: occlusions and aneurysms
  • Biopsy of muscles, liver, kidneys, skin and subsequent histopathological examination.

Note: The American College of Rheumatology has developed classification criteria for polyarteritis nodosa.

Treatment[edit | edit source]

Corticosteroids are mainly used in the treatment, in severe cases they are combined with cyclophosphamide (pulses of methylprednisolone + cyclophosphamide at a dose of 10–15 mg / kg at weekly to monthly intervals).

Sources[edit | edit source]

Related articles[edit | edit source]

Used literature[edit | edit source]

Category:Internal medicine Category:Angiologiy Category:Pathology Category:Dermatovenerology