Nephrogenic diabetes insipidus

Nephrogenic diabetes insipidus is a rare inherited disease linked to the chromosome X (mutation vasopressin receptor gene or aquaporin 2 gene).

• Acquired form much more common: may occur in patients with nephropathy affecting the marrow kidneys + distal tubules ( polycystic kidney disease | polycystic kidney disease, chronic pyelonephritis, etc.), when administration of certain drugs (Li);
• inability of tubular cells to respond to ADH (normal blood concentration).

Clinical symptoms

• Polyuria + polydipsia;
• hypernatremia;
• hyperthermia;
• mental retardation.

Diagnostics

• Dg. determined using a concentration test with exogenous ADH.

Therapy

• Adequate fluid intake;
• restrictions Na in the diet, hydrochlorothiazide / indomethacin.

Links

Related articles

• Diabetes insipidus
• ADH