Carbohydrate digestion

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Carbohydrates are taken in food mainly as polysaccharides, disaccharides and monosaccharides.

The main polysaccharide is vegetable starch, composed of amylopectin and amylose. Glucose molecules are arranged in it in straight or slightly branched chains and are bound by 1,4 α-glycosidic bonds. The polysaccharide of animal origin is glycogen, which is made up of glucose molecules with branched chains connected by 1,6 α-glycosidic bonds. Disaccharides include sucrose (beet sugar) and lactose (milk sugar). Monosaccharides include glucose and fructose.

Cellulose, hemicellulose and pectin belong to indigestible plant polysaccharides, so they have no nutritional value for humans, but are part of fiber in food. Fiber is indigestible for humans, but it is digestible by colon bacteria, it also lowers cholesterol and is important in the prevention of colon cancer. It is important in the regulation of intestinal functions.

Starch digestion begins in the mouth by the action of the salivary gland enzyme - ptyalin. Its activity is attenuated in the acidic stomach contents and then continues in the duodenum by the action of pancreatic α-amylase. Alkaline pancreatic juice neutralizes the acidic chyme entering the duodenum from the stomach and thus enables the action of pancreatic amylase, which completes the breakdown of starch and glycogen into simpler carbohydrates (maltose, maltotriose and oligosaccharides, primarily α-dextrin).[1]

The actual resorption of carbohydrates takes place only at the level of monosaccharides, the enzymes of the brush border of the enterocyte membrane must complete the cleavage of the resulting oligosaccharides.

Absorption of carbohydrates

Carbohydrate absorption[edit | edit source]

The end products of digestion are simple sugars - glucose, galactose and fructose. The resulting monosaccharides are subsequently transported to the enterocytes. Glucose and galactose use secondary active transport with Na+ ions using the transporter SGLT-1 and 2, fructose passes into the enterocyte facilitated diffusion using the transporter GLUT- 5.[1]

Glucose passes from the enterocyte by facilitated diffusion using the transporter GLUT-2 further into the veins collecting into the vein portae, fructose is mostly converted to glucose via fructose-6-phosphate and glucose-6-phosphate, a smaller part it also enters the blood via the GLUT-2 transporter.[1]


Links[edit | edit source]

Related articles[edit | edit source]

Literature[edit | edit source]

  • KITTNAR, Otomar. Lékařská fyziologie. 1. edition. Grada, 2011. ISBN 978-80-247-3068-4.
  • SILBERNAGL, Stefan – DESPOPOULOS, Agamemnon. Atlas fyziologie člověka. 6. edition. Grada, 2011. ISBN 978-80-247-0630-6.
  • GANONG, William F. Přehled lékařské fyziologie. 20. edition. Galén, 2005. 890 pp. ISBN 80-7262-311-7.

References[edit | edit source]

  1. a b c GANONG, William F. Přehled lékařské fyziologie. 20. edition. Galén, 2005. 890 pp. ISBN 80-7262-311-7.