B - Lymphocytes

From WikiLectures

Plasma cell
Lymphocyte in ELMI

B-lymphocytes represent the basic cells of antibody immunity.

They are formed in bone marrow, where they also mature. There is no selection during their development (as with T-ly. Their maturation takes place after encountering antigen in secondary lymphatic organs.The final differentiation stage of B-lymphocytes is "plasma cells" producing antibodies to protein and glycoprotein antigen and toxins.

Development line
Pluripotent stem cell → lymphoid progenitor → B-lymphocytes → plasma cells (plasma cells) producing immunoglobulins and memory cells.

The B-cell receptor is 'BcR' (B-cellular receptor). It consists of its own surface immunoglobulin (IgM, IgD) and associated signaling molecules.[1] The IgM monomer is anchored to the membrane by its "Fc fragment", which is different from normal Fc (it is longer, it contains a component that holds it in the membrane). Other antigenic structures are CD-19, CD-20 (typical of mature B-lymphocytes), CD-10 (only at some stage of immature cells, in some leukemic lines). Some B-lymphocytes change into "memory B-ly" upon encounter with antigen and clonal proliferation. These are part of the 'immune memory' . They are responsible for significantly accelerating the "secondary immune response" upon repeated encounters with antigen (important for vaccination).

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  1. Incomplete citation of publication.  – BARTŮŇKOVÁ, Jiřina. Basics of immunology. Triton, 2009. 0 pp. pp. 61. ISBN 978-80-7387-280-9.

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