Acquired defects of factors II, V, VII, IX and X

Acquired defects of factors II, V, VII, IX and X arise in advanced liver diseases, [vitamin K]] deficiency/inhibition.

Absorption disorder of vit. K: obstructive jaundice, malabsorption syndrome (pancreatic / intestinal origin),
coumarin preparations act as inhibitors of vit. K (warfarin, see figure),
in liver diseases, the production of f. II, VII, IX, X, V decreases gradually; u go ahead conditions complex disorder of hemostasis + in addition thrombocytopenia (with splenomegaly), increased fibrinolytic activity (portocaval anastomoses + ↓ detoxification capabilities of the liver),
in liver diseases, hemorrhagic conditions of varying severity, threat to hl. bleeding into the GIT.

Lack of vit. K / overdose of coumarin → administration of vit. K (Kanavit),
at hep. replacement disease: K-plasma, prothrombin complex concentrates, fresh frozen plasma,
antifibrinolytics + glucocorticoids.

Links[edit | edit source]

KLENER, Pavel, et al. Vnitřní lékařství. 3. edition. 2006. ISBN 80-7262-430-X.

Poruchy hemostázy WikiSkripta. Poruchy hemostázy - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Poruchy_hemost%C3%A1zy>.