Precancers in dermatology

Leukoplakia on buccal mucosa

in a broader sense, they are chronic manifestations of various origins, long-term irritation stimulates the tissue to proliferate (chronic ulcers, lupus vulgaris, scars, etc.)
in and around these processes, there are warty exuberant granulations - mimicking a tumor - pseudoepitheliomatous hyperplasia'' or paratypic proliferation
in the narrower sense of the word – separate clinical units, from which a tumor develops more often if it lasts long enough...

= keratosis solaris, keratosis actinica

in old people in places exposed to the sun and external influences, manifestations usually like degeneratio cutis senilis'
epidermal dysplasia
sharply defined focus of gray to red color, rough surface, covered with hyperkeratotic scales, later becomes moist, then bleeds and ulcerates
turns into cancer (mainly squamous cell)

Cornu cutaneum

does not differ from keratome, a horn-shaped formation grows on the surface, even several cm, the base can change into a spinocele. carcinoma

typical precancer of mucous membranes, whitish, opalescent, sharply demarcated deposits
later the bearing can be:
- elevated - leukoplakia simplex,
- with a thickened to verrucous surface - leukoplakia verrucosa,
- can erode - leukoplakia erosiva.
effects of formation - smoking, mechanical irritation, chemical effects,...
must distinguish lichen ruber!=== Lentigo maligna ===
irregular brown to black deposit, irregular pigmentation
slowly expanding into an area
mainly face, men around 60 years old
the result of long-term exposure to UV radiation
proliferation of atypical melanocytes in the epidermis
risk of transition to malignant melanoma - lentigo maligna melanoma

Links[edit | edit source]

STORK, George. Dermatovenereology. 2. edition. Galen, 2013. 502 pp. ISBN 978-80-7262-898-8.