Kinin cascade

The kinin cascade is the fourth important plasma cascade system, next to the coagulation, fibrinolytic and complement cascades. Its main end product is bradykinin, a substance with a number of physiological effects, which is mainly used in inflammation, edemas, and pain ^[1].

Bradykinin[edit | edit source]

Bradykinin

Bradykinin is a nonapeptide with powerful biological activity that:

causes vasodilatation,
increases vascular permeability,
causes hypotension,
stimulates nociceptors, participates in pain perception,
induces smooth muscle contraction in a number of locations,
activates phospholipase A2 and cellular metabolism arachidonic acids.

Kinin Cascade Proteins[edit | edit source]

Four protein components are involved in the formation of bradykinin, which are synthesized in the liver:

coagulation factor XII (Hageman factor),
coagulation factor XI,
prekallikrein,
high molecular weight kininogen.

Links[edit | edit source]

References[edit | edit source]

↑ SILBERNAGEL, S – LANG, F. Atlas of human pathophysiology. 1. edition. Prague : Grada Publishing, 2001. 404 pp. ISBN 80-7169-968-3.

Literature[edit | edit source]

STITES, Daniel P – TERR, Abba I. Basic and Clinical Immunology. 1. edition. Victoria Publishing, 1994. ISBN 80-85605-37-6.

[silbernagl-1] SILBERNAGEL, S – LANG, F. Atlas of human pathophysiology. 1. edition. Prague : Grada Publishing, 2001. 404 pp. ISBN 80-7169-968-3.

[1]