Ito Cells

Schematic representation of the structure of the liver lobule. It's cells are labeled as "stellate cells".

Ito cells (stellate cells) are cells of mesenchymal origin located in the perisinusoidal space of the liver lobules. Their cytoplasm contains large lipid droplets used to store vitamin A. Under certain pathological circumstances, e.g. after injury, alcohol damage or infection, Ito cells can differentiate into myofibroblast-like cells and synthesize excessive amounts of extracellular matrix, especially collagen type I and III. Thereby they cause fibrotization of the liver. Ito cells are also significantly involved in liver regeneration.

Liver as a histological preparation:

References

  • LÜLLMANN-RAUCH, Renate. Histologie. 1. edition. Praha : Grada, 2012. 576 pp. ISBN 978-80-247-3729-4.
  • MESCHER, Anthony L – JUNQUEIRA, Luiz Carlos Uchôa. Junqueira's Basic Histology. 12. edition. United States : McGraw-Hill Education - Europe, 2009. 480 pp. ISBN 9780071630207.
  • VÁLEK, Vlastimil – KALA, Zdeněk, et al. Maligní ložiskové procesy jater :  diagnostika a léčba včetně minimálně invazivních metod. 1. edition. Praha : Grada, 2006. ISBN 80-247-0961-9.