Cryptococcus neoformans

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It is a yeast-type fungus that causes cryptococcosis (a generalized disease affecting several organs).[1]

Morphology[edit | edit source]

Cells 5-15 μm in size are spherical in shape and propagate by budding. They do not form pseudohyphae. On the cell surface, there is a wide mucus sheath, which is an important factor in virulence because it protects the cryptococcus from phagocytosis.

Epidemiology[edit | edit source]

Cryptococcus is a common saprophyte in soil, plants and a number of animal hosts. Typical sources of infection are the nests of birds and their droppings (mainly pigeons). A person is most often infected by inhaling an unencapsulated fungus, sometimes through Skin (benign form).

Pathogenesis[edit | edit source]

The disease it causes is called cryptococcosis.

These can be:

  • primary mycosis in healthy individuals,
  • secondary mycosis (often in patients with AIDS).

Cave!!!.pngIt is at the front site among the infirmity of mycotic complications in individuals with AIDS.

They have primarily affected lungs, dangerous hematogenous spread to various organs is dangerous. A serious and typical localization is CNS.

Laboratory diagnostics[edit | edit source]

Depending on the form of the disease, we examine cerebrospinal fluid, sputum, urine or blood culture. Microscopically, we see typical budding cells with a wide capsule. Antibodies are minimally produced, serological testing is therefore irrelevant.

Cultivation[edit | edit source]

They are not cultivation demanding. They grow for 5-10 days at 37 ° C and 20 ° C. On Sabourad's land, they grow in the form of yellow and strikingly shiny colonies.

Treatment[edit | edit source]

We administer antifungals (amphotericin B, fluconazole).

Links[edit | edit source]

Related articles[edit | edit source]

References[edit | edit source]

  1. ROSYPAL, Stanislav. Bakteriologie a virologie. 1. edition. 1994. ISBN 80-85827-16-6.

Sources[edit | edit source]

BEDNÁŘ, M. Lékařská mikrobiologie. 1. edition. 1996. ISBN 80-238-0297-6.