Coenzyme A
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Coenzyme A, referred to in the literature as HSCoA or just CoA, belongs to the group-transferring enzymes.
Its ability to transfer groups is used by ``synthetases, which generate activated acyls, i.e. acyl−CoA, the best known of which is acetyl−CoA during the hydrolytic splitting of ATP with the help of coenzyme A ]. These acyl−CoAs contain a thioester bond in which the remainder of the carboxyl group is attached to the -SH group of coenzyme A. The important thing about acyl−CoAs is that many important reactions take place on their β−carbon (i.e. C2 acyl) thanks to the activation of hydrogens. The best known are dehydration' in β-oxidation of fatty acids or condensation in the reaction of acetyl−CoA with oxaloacetate in the Krebs cycle.
Structure of Coenzyme A molecule[edit | edit source]
The vitamin precursor for coenzyme A is pantothenic acid (vitamin B5), consisting of pantoic acid and β-alanine. Other structural components of coenzyme A are the biogenic amine cysteamine and adenosine-3'-phosphate-5'-diphosphate.
2: diphosphate
3: pantoic acid
4: β-Alanine
5: cysteamine
1+2: adenosine-3'-monophosphate-5'-diphosphate
3+4: pantothenic acid
3+4+5: pantetheine
Links[edit | edit source]
Related Articles[edit | edit source]
Source[edit | edit source]
- KODÍČEK, Milan. Biochemical terms: explanatory dictionary [online] . 1. edition. Prague : VŠCHT, 2004. 171 pp. Available from <http://147.33.74.135/knihy/uid_es-002_v1/hesla/koenzym_a.html>. ISBN 80-7080-551-X.
References[edit | edit source]
- MATOUŠ, Bohuslav, et al. Basics of medical chemistry and biochemistry. 1. edition. Prague : Galen, 2010. 540 pp. ISBN 978-80-7262-702-8.
