Coenzyme A

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Last update: Friday, 24 Nov 2023 at 6.25 pm.

Coenzyme A, referred to in the literature as HSCoA or just CoA, belongs to the group-transferring enzymes.


Its ability to transfer groups is used by ``synthetases, which generate activated acyls, i.e. acyl−CoA, the best known of which is acetyl−CoA during the hydrolytic splitting of ATP with the help of coenzyme A ]. These acyl−CoAs contain a thioester bond in which the remainder of the carboxyl group is attached to the -SH group of coenzyme A. The important thing about acyl−CoAs is that many important reactions take place on their β−carbon (i.e. C2 acyl) thanks to the activation of hydrogens. The best known are dehydration' in β-oxidation of fatty acids or condensation in the reaction of acetyl−CoA with oxaloacetate in the Krebs cycle.

Structure of Coenzyme A molecule[edit | edit source]

The vitamin precursor for coenzyme A is pantothenic acid (vitamin B5), consisting of pantoic acid and β-alanine. Other structural components of coenzyme A are the biogenic amine cysteamine and adenosine-3'-phosphate-5'-diphosphate.

File:Coenzyme A beschriftet.svg
1: adenosine-3'-phosphate
2: diphosphate
3: pantoic acid
4: β-Alanine
5: cysteamine
1+2: adenosine-3'-monophosphate-5'-diphosphate
3+4: pantothenic acid
3+4+5: pantetheine

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References[edit | edit source]

  • MATOUŠ, Bohuslav, et al. Basics of medical chemistry and biochemistry. 1. edition. Prague : Galen, 2010. 540 pp. ISBN 978-80-7262-702-8.