Antibody class switching
From WikiLectures
Isotype switching (or class switch) arises:
- IgH gene complex after V-D-J rearrangement,
- cleavage of a loop between two rearrangement sequences before Cμ and some other C gene segment,
- gene complex after cleavage of part of the C-region,
- by transcription into RNA and splicing of the primary transcript mRNA encoding a certain immunoglobulin isotype is generated,
- rearrangements can take place sequentially as long as there is something to eliminate,
- what rearrangement occurs is regulated by cytokines,
- IL-4 stimulates the production of IgE, IgG1, inhibits IgG2,
- IFN-γ, TGF-β.
Links[edit | edit source]
Related articles[edit | edit source]
Bibliography[edit | edit source]
- HOŘEJŠÍ, Václav – BARTŮŇKOVÁ, Jiřina. Základy imunologie. 3. edition. Praha : Triton, 2008. 280 pp. ISBN 80-7254-686-4.
