Von Graefe's sign

Looking down, the movement of the upper eyelid is delayed by the movement of the bulbus and a sclera crescent appears above the iris. This Symptom is typical for hyperthyroidism and Graves disease and indicates exophtalmic goiter. See the video below for better understanding.



References

KLENER, P.. Vnitřní lékařství. 3.. edition. 2006. ISBN 80-7262-431-8.