Type 2 diabetes mellitus (biochemistry)

From WikiLectures

Type 2 is the predominant form of DM. Patients are not vitally dependent on exogenous insulin because insulin production is not reduced or is reduced less than in type 1 DM .

The cause of this type is a breakdown in the action of insulin . This is the so-called insulin resistance due to a disorder of the insulin receptor or a disorder in the transmission of the insulin signal to the cell.

Insulin levels in the blood tend to be increased initially due to insulin resistance . In the further course of the disease, a disorder of insulin secretion also begins , β-cells gradually lose the ability to respond to increased glucose levels by insulin synthesis.

The disease manifests itself mainly in adulthood, usually over the age of 40. Type 2 DM has a high heredity, so the family burden is evident in the anamnesis. Unlike type 1, patients are not prone to ketoacidosis. 60-90% is associated with obesity.

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