TPHA
From WikiLectures
TPHA (Treponema pallidum hemagglutination) is a syphilis screening test.
- The antigen is T. pallidum ssp. Pallidum Nichols (so-called Nichols strain) bound to chicken erythrocytes. Agglutination occurs when this antigen meets serum antibodies.[1]
- The sensitivity of TPHA in primary syphilis is 69-90%, in secondary syphilis 100%, and later around 97%.
- The specificity of this test is at least 98%.[2]
