TPHA

TPHA (Treponema pallidum hemagglutination) is a syphilis screening test.

  • The antigen is T. pallidum ssp. Pallidum Nichols (so-called Nichols strain) bound to chicken erythrocytes. Agglutination occurs when this antigen meets serum antibodies.[1]
  • The sensitivity of TPHA in primary syphilis is 69-90%, in secondary syphilis 100%, and later around 97%.
  • The specificity of this test is at least 98%.[2]


References

  1. ↑ http://mikrobiologie.lf3.cuni.cz/mikrobiologie/bak/uceb/obsah/lues/lues.htm
  2. ↑ http://www.medmicro.info/portal/syfilis/lvl3/ch09s05.html

Category: Infectious MedicineCategory: Dermatovenerology