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Renin is an enzyme that is produced and secreted by the juxtaglomerular cells of the kidney. The stimulus for its secretion is a drop in blood pressure. Renin catalyzes the conversion of angiotensinogen (or renin substrate) to angiotensin I, which is also enzymatically converted to angiotensin II. The conversion of angiotensin I to angiotensin II is catalyzed by angiotensin-converting enzyme (ACE), which is mainly found in the endothelial cells of the pulmonary vessels.

Angiotensin II increases blood pressure by two main mechanisms – vasoconstriction and renal water and salt retention.

Angiotensin I has only a mild vasoconstrictive effect and renin has no vasoactive effects.

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GUYTON, Arthur C – HALL, John E. Textbook of Medical Physiology. 10. edition. Philadelphia, Pa.; W. B. Saunders, c2000. 2000. 0 pp. ISBN 72168677X.