Regulation of ketogenesis
From WikiLectures
Regulation of ketogenesis takes place at four levels:
- Hormone-sensitive lipase – lipolysis in adipose tissue.
- Carnitine acyltransferase I – entry of fatty acids into mitochondria, where their β-oxidation takes place.
- Routing of acetyl-CoA from β-oxidation to ketogenesis and not to the Krebs cycle .
- Mitochondrial HMG-CoA synthase.
A high level of ketone bodies in the blood signals the presence of a large amount of acetyl-CoA. Its consequence is the inhibition of lipolysis.
