Post-translational Modifications

Post-translational modifications begin after successful translation. They include:

Removing the first Met from the N-terminal of the polypeptide
Removal of the so-called signal peptide from the N-terminal
in the case of some protein hormones, the resulting peptide molecule is further split - e.g. the formation of insulin :
- is produced as preproinsulin
- removal of the signal peptide produces proinsulin
- after the formation of disulfide bonds, a section of length 31AA - the so-called C peptide - is cleaved from proinsulin
- the definitive insulin molecule then consists of A and B chains connected in a characteristic spatial arrangement by disulfide bridges

Links[edit | edit source]

ŠTEFÁNEK, Jiří. stefajir : Medicine, diseases, studies at the 1st Faculty of Medicine, UK [online]. [cit. 2009]. <http://www.stefajir.cz>.

MURRAY, Robert K. – GRANNER, Daryl K. – MAYES, Peter A.. Harper’s Biochemistry. 23.. edition. Appleton & Lange, 1993. ISBN 0-8385-3562-3.

ALBERTS, – JOHNSON, Alexander – LEWIS, Julian. Molecular Biology of the Cell [online] . 5.. edition. Garland, 2007. Available from <https://www.ncbi.nlm.nih.gov/books/NBK21054/>. ISBN 978-0-8153-4111-6.

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