Peroxisomal leukodystrophy
Peroxisomal leukodystrophies are leukodystrophies, that are caused by a malfunction of peroxisomes[1], subcellular organelles involved in many metabolic pathways - the formation and degradation of hydrogen peroxide (catalase), fatty acid oxidation, cholesterol and dolichol synthesis, etc.[2]
Peroxisomal disorders can be divided into two categories:
- disorder of peroxisomal biogenesis − typical representatives are Zellweger syndrome and neonatal adrenoleukodystrophy
- defects of individual peroxisome enzymes − representative is X-linked adrenoleukodystrophy.[1]
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Related articles
- Peroxisome
- Peroxisomal disease
- Leukodystrophy
- X-linked adrenoleukodystrophy
- Neonatal adrenoleukodystrophy
- Zellweger syndrome
External links
Reference
- ↑ a b GOETZ, Christopher G – GOETZ, Christopher G. Textbook of clinical neurology. 3. edition. Saunders Elsevier, 0000. 0 pp. ISBN 1-4160-3618-0.
- ↑ COOPER, Geoffrey M. NCBI [online]. [cit. 2011-12-07]. <https://www.ncbi.nlm.nih.gov/books/NBK9930/>.
