Oxidation of unsaturated fatty acids

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Most of the unsaturated fatty acids in the human body and in food have a cis configuration of double bonds. Their degradation in β-oxidation proceeds by the process described above until their double bond comes into contact with enoyl-CoA hydratase. This requires only trans isomers – it is therefore necessary to convert the cis isomer to trans using an isomerase.

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Fontana J., Trnka J., Maďa P., Ivák P. a kol.: Transformation of substances and energy in the cell. In: Functions of cells and the human body : Multimedia scripts. Available online from: [1]