Non-alcoholic steatohepatitis

From WikiLectures

Definition, pathogenesis, sypmtoms, complication, therapy.

Hepatic steatosis is a condition in which the amount of fat (especially triacylglycerols) in the liver exceeds 5% of its weight.

  • increased dietary fat intake;
  • increased mitochondrial fatty acid synthesis or decreased oxidation;
  • impaired release of triacylglycerols from the hepatocyte;
  • excess sugars, which are converted into fatty acids;
  • hyperalimentation, diabetes mellitus, Wilson's disease, parenteral nutrition, Reye's syndrome.
Clinical picture
  • asymptomatic course or non-specific symptoms: hepatomegaly, abdominal pain, + symptoms of the underlying disease;
  • slightly elevated aminotransferases, hypertension, hypertriacylglycerolemia, insulin resistance;
  • liver ultrasound: increased echogenicity;
  • histological picture (small or large droplet, simple steatosis or steatohepatitis);
  • elimination of the cause, treatment of metabolic disease.

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