Monitoring in neurointensive care
Methods specific to neurointensive care can be broadly divided into methods looking at global parameters and focal parameters in the area of interest.
Global parameters include jugular oximetry, intracranial pressure monitoring and transcranial doppler ultrasonography.
Methods applied in monitoring focal involvement include microdialysis and intraparenchymal monitoring of partial tension of O2 and CO2, pH and temperature.
Measurement of intracranial pressure[edit | edit source]
Nowadays, pressure sensors inserted directly into the tissues are used to monitor intracranial pressure. For multimodal bedside monitoring, the currently used equipment is oxygen and thermal sensors, sensors determining the partial tension of CO2 and pH, and microdialysis catheters.
Currently, intraparenchymatous monitoring of intraluminal pressure is most widely used. The pressure sensor is introduced from a projection over the nondominant hemisphere (1 cm anterior to the coronary suture) in the sagittal plane interleaved with the pupil of the corresponding side.
A unique technology at present is a multimodal sensor allowing measurement of pHti, ptiCO2 and ptiO2. The next letter after the subscript "ti" (tissue = tissue) indicates the type of tissue, e.g. Ptib (b = brain) is the partial pressure of oxygen in the brain, Ptim (m = muscle) in muscle, etc. Other modalities are also used - pH sensors, pCO2 sensors, oxygen and temperature sensors.
Microdialysis[edit | edit source]
Microdialysis is not yet a standard method of brain monitoring, but its use in clinical practice may have a major impact on the quality of neurointensive care in the future. It is a method of monitoring metabolic changes in the intercellular space. A microdialysis catheter is inserted into the brain tissue. Ringer's solution flows through the system at a rate of 0.3 μl/min. The micro-volumes are then analyzed in a liquid chromatograph.
The standard metabolic profile includes: lactate, pyruvate, glutamate, glucose and glycerol.
In addition to the catheter inserted into the damaged area (the worse side), a reference catheter is inserted into the undamaged tissue (the better side) and a catheter that should reflect systemic changes (the best side). The latter is inserted into the subcutaneous adipose tissue in the abdominal region.
Use of spectroscopy near Infrared radiation (near infrared spectroscopy; NIRS)[edit | edit source]
The method is based on the finding that light falling in the near-infrared region can penetrate skin and bone.
The absorption of this radiation by brain tissue depends on the concentrations of haemoglobin, oxygenated and deoxygenated. These haemoglobins show different absorption of light. By analysing the changes in absorption it is possible to obtain information on the oxidative state of the brain tissue.
The clinical application of the method is based on the use of small optical sensors connected to a monitor. Optical electrodes are placed in the frontal region at a distance of 4-7 cm. The method is capable of analysing approximately 10 cm3 of tissue. Its general disadvantage is the inability to differentiate between extracranial and intracranial flow changes.
Jugular Oximetry[edit | edit source]
Jugular oximetry measures oxygen saturation in the jugular bulb (SjvO2), which is a reflection of global cerebral oxygenation or perfusion.
Transcranial doppler ultrasonography[edit | edit source]
TCD is used to monitor blood flow velocity in the basal arteries and carotid arteries. It is used to diagnose vasospasm and regional perfusion disturbances that may accompany brain trauma or subarachnoid hemorrhage.
Bispectral Index (BIS)[edit | edit source]
The bispectral index is a form of EEG monitoring of depth of sedation and anesthesia.
The result of software signal processing is a dimensionless number on a scale of 0 to 100, where a value of 100 corresponds to full consciousness, 80-65 to sedation, 65-40 to moderate to deep anaesthesia, and values < 40 represent coma. Optimal values for surgical procedures are 40-60.
The index has very high validity as documented by studies in adult patients during inhalational anaesthesia. The use of the method in paediatric anaesthesia and in intensive care beds is still under investigation.
A limitation of the method in children is the large variability of values for adequate analgosedation (a particular value in one patient may indicate a good level of analgosedation, while the same value in another patient may not). Nevertheless, there are a number of studies in pediatric patients that demonstrate the benefit in improving titration of sedation and the objectivity (quantification) of the assessment of depth of sedation.
| Value of BIS | State of consciousness |
|---|---|
| 100 | full consciousness |
| 80–65 | sedation |
| 65–40 | medium to deep anaesthesia |
| < 40 | coma |
Links[edit | edit source]
Related Articles[edit | edit source]
Source[edit | edit source]
HAVRÁNEK, Jiří: Ostatní monitoring.
