Medullary thyroid cancer
From WikiLectures
Medullary thyroid cancer is derived from parafollicular C-cells thyroid gland. In four clinical forms:
- sporadic (70–80 % of carcinomas, most aggressive)
- familial (AD heritance)
- MEN 2A and MEN 2B (together with pheochromocytoma, neurofibroma, parathyroid gland adenoma,...)
Clinical picture + diagnostics[edit | edit source]
- Similar to differentiated thyroid cancer,
- secrets calcitonin (tumor marker),
- is more aggressive than differentiated carcinoma, at the time of diagnosis metastasis are in more than 50% of cases,
- in medullary thyroid carcinoma in connection with MEN 2A and MEN 2B, vanillic acid is measured,
- 50% of medullary carcinomas produces CEA (carcinoembryonic antigen).
Therapy[edit | edit source]
Totální thyreoidektomie, zevní ozáření (C buňky neakumulují jód), chemoterapie. Total thyroidectomy, external radiation (C cells do not accumulate iodine), chemotherapy.
Prognosis[edit | edit source]
Despite the aggressiveness, prognosis is favorable - 75% of patients survive 15 years.
References[edit | edit source]
Related articles[edit | edit source]
Used literature[edit | edit source]
- DÍTĚ, P.. Vnitřní lékařství. 2. edition. Praha : Galén, 2007. ISBN 978-80-7262-496-6.
- BENEŠ, Jiří. Studijní materiály [online]. ©2007. [cit. 2016]. <http://jirben.wz.cz>.
