Calcitonin
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Calcitonin, (thyrocalcitonin, CT), is a peptide hormone produced by the parafollicular (C-cells) of the thyroid gland. Its concentration increases with hypercalcemia. It lowers the level calcium ions in the blood and thus represents an antagonist to the parathormonu produced by the main cells of the parathyroid bodies. Parathormon and calcitonin stimulate reabsorption in the ascending part of the loop of Henle, where calcium is reabsorbed transcellularly and paracellularly [1] Parathormone reduces the resulting concentration of calcium in the urine, calcitonin increases it. In the distal part of the nephron, in addition to parathyroid hormone and calcitonin, calcitriol also participates in reabsorption of calcium.
Calcitonin:
Effects of calcitonin[edit | edit source]
- Bone: retains Ca + P
- kidney: reduces reabsorption of Ca + P
- intestine - no direct effect (calcitonin most likely reduces the formation of calcitriol in the kidneys).[2]
Benchmarks[edit | edit source]
men, normal laboratory value: 3-26 ng/l women, normal laboratory value: 2-17 ng/l
The regulation of calcium in the organism[edit | edit source]
| Parathormon | Calcitonine | Vitamin D [2] | |
|---|---|---|---|
| bone | osteoclast activation,
calcemia and phosphatemia rise |
inhibition of osteoclasts,
deposition of Ca 2+ in bones |
skeletal mineralization;
high levels, on the other hand, decalcify |
| kidneyx | stimulates Ca 2+ resorption, inhibits phosphate resorption,
stimulates vitamin D synthesis |
increases the excretion of Ca 2+ ,
increases the excretion of phosphates |
increases the reabsorption of Ca 2+ and phosphates |
| intestine | stimulates resorption of Ca 2+ and phosphates | – | stimulates resorption of Ca 2+ and phosphates |
Links[edit | edit source]
Related articles[edit | edit source]
References[edit | edit source]
- ↑ WILHELM, Z. Co je dobré vědět o vápník. Praktické lékárenství [online]. 2007, y. -, p. 184-189, Available from <http://solen.cz/pdfs/lek/2007/04/09.pdf>.
- ↑ a b SILBERNAGL, Stefan – DESPOPOULOS, Agamemnon. Atlas fyziologie člověka : 6. vydání, zcela přepracované a rozšířené. 3. edition. Praha : Grada, 2004. pp. 290-293. ISBN 80-247-0630-X.
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Other links[edit | edit source]
References[edit | edit source]
- VÁCLAVA, Václava – VAJNER, Luděk. Funkční histologie. 1. edition. Jinočany : H & H, 2000. ISBN 80-86022-80-3.
- VOKURKA, Martin – HUGO, Jan. Velký lékařský slovník. 9. edition. Praha : Maxdorf, 2009. 1159 pp. ISBN 978-80-7345-202-5.
