Malignant hyperthermia

From WikiLectures

Malignant hyperthermia is an AD hereditary disease in which the calcium metabolism of the muscle cell is disturbed . In predisposed individuals, upon contact with triggers, an uncontrollable muscle contraction occurs, leading to a hypermetabolic reaction of the organism. The amount of CO2, lactate, heat increases. Severe rhabdomyolysis and multi-organ failure and death may occur. The triggering moment can be stress or general anesthesia!

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  • BLATTEIS, Clark M. Physiology and Pathophysiology of Temperature Regulation. - edition. Singapore : World Scientific, 1998. ISBN 978-02-3172-5.