|leptin receptors in the hypothalamus and arcus arcuatum |
Leptin (from the greek leptos − narrow, thin) is a hormone produced by cells of adipose tissue − adipocytes. Leptin production increases with the amount of fat in the cells. In general, a low leptin concentration signals starvation. Most obese patients have hyperleptinemia. Leptin regulates food intake and energy expenditure. Peripherally affects insuline sensitivity. Phylogenetically designed to adapt the body to long-term starvation.
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- PAN, Haitao – GUO, Jiao – SU, Zhengquan. Advances in understanding the interrelations between leptin resistance and obesity. Physiol Behav [online]. 2014, vol. 130, p. 157-69, Available from <https://www.ncbi.nlm.nih.gov/pubmed/24726399>. ISSN 0031-9384 (print), 1873-507X.