LRO

• LRO stands for lysosome related organelles, which in translation are lysosome like organelles that have the membrane parameters of lysosomes and some of their enzymes, but only residual or zero degradation activity, unlike lysosomes.

• these organelles include:
  • azurophilic granules of eosinophilic and neutrophilic granulocytes, the disorders of which lead, among other things, to intestinal diseases
  • melanosomes of melanocytes, whose deficiency leads to a certain type of albinism
  • delta granule thrombocytes, whose disorder leads to increased bleedingthrombocytes
  • lytic granules of NK cells and Tc lymphocytes, the disorder of which leads to immunodeficiency
  • secondary granule of pneumocytes II. order, the disorder of which leads to pulmonary fibrosis
  • osteoclasts lysosomes

• Chédiak-Higashi syndrome and Heřmanský-Pudlák syndrome are among the syndromes in which there is a disorder in the LRO.

• ws:LRO