From WikiLectures

Isoprenaline is a non-selective β-receptor agonist with effects similar to adrenaline.

Effects[edit | edit source]

  • stimulation of β1-adrenergic and β2-adrenergic receptors
  • increase in strength of myocardial contraction (positive inotropic effect)
  • significant increase in heart rate
  • vasodilatation in the pulmonary vascular bed without affecting the flow through the renal and mesenteric vascular bed

Side effects result from the mechanism of action – an increase in heart rate with a decrease in the availability of oxygen to the myocardium, a proarrhythmogenic effect.

Indication[edit | edit source]

  • during circulatory collapse (shock) with a decrease in cardiac output and an increase in central venous pressure
  • prevention of brochospasm and pulmonary hypertension during anesthesia
  • in the treatment of permanent bradycardia, conduction disorders - AV blockade, until the introduction of cardiac stimulation
  • therapy Adams-Stokes syndrome

Contraindications[edit | edit source]

  • sinus tachycardia higher than 130/min
  • atrial and ventricular hyperexcitation
  • digitalis intoxication
  • acute coronary insufficiency, acute myocardial infarction - except in the case of simultaneous AV block with extreme bradycardia
  • simultaneous administration with adrenaline is contraindicated

Links[edit | edit source]

Related Articles[edit | edit source]

References[edit | edit source]

  • LINCOVÁ, Dagmar – FARGHALI, Hassan, et al. Basic and applied pharmacology. 2. edition. Prague : Galen, 2007. 672 pp. pp. 90–96. ISBN 978-80-7262-373-0.