From WikiLectures

OSC Microbio 17 01 Cytokine.jpg

The humoral signaling molecules that cells of the immune system use to communicate with each other are called cytokines. A very important group of cytokines are the interleukins (ILs). These are mostly short peptide chains. Their effects are both autocrine, paracrine and endocrine. They serve as humoral communication between specific immunity and natural immunity cells. They are produced mostly by helper T-ly, APCs and macrophages.

Function overview[edit | edit source]

Interleukins have very different functions. An overview of the most important ones is given in the table.

IL-1 initiates inflammation response (fever), activates other cells
IL-2 activates T-lymphocytes and B-lymphocytes, macrophages, neutrophils
IL-3 promotes proliferation of white blood cells (myeloid and lymphoid progenitor cells) - see


IL-4 Th2-ly subset support, plasma cell maturation and antibody class switching
IL-5 promotion of proliferation and differentiation of eosinophils and T-ly
IL-6 systemic inflammatory response (fever), promotion of T-ly, B-ly
IL-7 proliferation and differentiation of lymphoid cells in the thymus
IL-8 chemotactic effects
IL-10 suppression of inflammatory response, promotion of Th2-ly subset
IL-12 increasing cytotoxicity (NK cells, Th1-ly, macrophages, neutrophils)
IL-13 attenuation of inflammatory reaction, inhibition of cytokine production

Links[edit | edit source]

Related articles[edit | edit source]

External links[edit | edit source]

  • ŠTERZL, Ivan, et al. Základy imunologie. 1. edition. Praha : Karolinum, 2005. ISBN 80-246-0972-X.