Hypovolemic state
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Dehydration is a hypovolemic state with a negative water balance (almost always associated with hyponatremia). It manifests itself with reduced skin turgor, dryness and stickiness of the mucous membranes and serosas, the cheeks are sunken and the nose protrudes sharply - facies Hippokratica .
Hyperosmolar dehydration[edit | edit source]
- serum concentration of Na + > 150 mmol/l
- greater loss of water than of solutes
- occurs either when hypoosmolar fluid is lost: vomiting, diarrhea, profuse sweating, disorders of urine production (polyuria in Acute failure, osmotic diuresis, central/peripheral diabetes insipidus) or when water intake is reduced: inability to drink, communicate, reduced thirst
- the reaction is a decrease in ECT osmolality and the movement of water from the cells (their volume decreases), a feeling of thirst, the concentration of plasma proteins increases
Isoosmolar dehydration[edit | edit source]
- serum concentration of Na + 150–130 mmol/l
- isoosmotic fluid loss
- burns, ascites buds, loss of blood or plasma, leakage of water into the third space (paralytic ileus,...), overdose of
diuretics (then K loss occur hard diarriha (!)
- the result is a decrease in the effective circulating volume of blood (fluid does not pass from the cells) - tachycardia, peripheral vasoconstriction, increase in blood pressure, activation of ADH a RAAS, concerted urine (without Na)
Hypoosmolar dehydration[edit | edit source]
- serum concentration of Na + < 130 mmol/l
- greater loss of solutes than water
- endocrine disorders (mineralocorticoid deficiency), lack of salt in the diet, nephritis with salt loss, osmotic diuresis, diuretic overdose, Bartte's syndrome (hypochloremic alkalosis with hypokalemia)
- the consequence is the movement of water into the cells (increasing their volume)
This division mainly helps in determining the cause of the pathological condition and the method of treatment.
Links[edit | edit source]
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External links[edit | edit source]
References[edit | edit source]
- NEČAS, Emanuel. Obecná patologická fyziologie. 2. vydání. Praha : Nakladatelství Karolinum, 2007. 377 s. ISBN 978-80-246-1291-1
