They belong to RNA viruses, in the genus Aphtovirus and contain 33 different serotypes.
Disease[edit | edit source]
- most infections occur inapparently (without clinical manifestations).
- about 5% of infections have clinical symptoms: febrile illness, myalgia, exanthems, meningitis, encephalitis, diseases of the respiratory and digestive system, pericarditis, hepatitis, pancreatitis,...
Most diseases will have severe consequences.
Pathogenesis[edit | edit source]
- gate of entry: mainly through food, exceptionally through the respiratory system
- multiplication in cells
- hematogenous spread
- the clinical consequences depend on the place of attachment of the virus and on the individual sensitivity of the individual.
- the virus is intensively secreted from the infected mucosa.
Diagnostics[edit | edit source]
- incubation from nasopharyngeal swabs, from stool, or from cerebrospinal fluid on cell cultures from monkey kidneys, or on mice.
- serological diagnosis using a neutralization test.
Epidemiology[edit | edit source]
The source of the virus is an infected person, who is already infectious at the end of the incubation period (3 to 7 days). The disease occurs mainly in summer and early autumn.
Links[edit | edit source]
References[edit | edit source]
- JIŘÍ, Horáček. Základy lékařské mikrobiologie. 1. edition. Praha : Karolinum, 2000. 309 pp. vol. 1. ISBN 80-246-0006-4.