They belong to RNA viruses, belong to the genus Aphtoviruses and contain 33 different serotypes.
Disease[edit | edit source]
- most infections occur inapparently (without clinical manifestations).
- about 5% of infections have clinical symptoms: febrile illness, myalgia, rash, meningitis, encephalitis, respiratory and digestive system diseases, hepatitis, pancreatitis, ...
Most diseases occur with severe consequences.
Pathogenesis[edit | edit source]
- gate of entry: mainly food, exceptionally the respiratory system
- multiplication in cells
- spread by the hematogenous route
- Clinical consequences depend on the site of virus attachment and the individual's sensitivity.
- the virus is intensively excreted from the infected mucosa.
Diagnostics[edit | edit source]
- incubation from nasopharyngeal swabs, faeces or cerebrospinal fluid on monkey kidney or mouse cell cultures.
- serological diagnostics using a neutralization test.
Epidemiology[edit | edit source]
The source of the virus is aninfected person who is infectious at the end of the incubation period (3 to 7 days). The disease occurs mainly in summer and early autumn.
Links[edit | edit source]
Literature[edit | edit source]
- HORÁČEK, Jiří. Základy lékařské mikrobiologie. 1. edition. 2000. ISBN 80-246-0006-4.