Disorders of uric acid metabolism/Questions and case studies
Questions[edit | edit source]
- In humans, carbamoyl phosphate is a precursor for the biosynthesis of:
- A – uridine monophosphate
- B – Inosine monophosphate
- C – urea
- D – glutamine
- The metabolites of vitamin B12 play a role in:
- A – Catabolism of fatty acids with an odd number of carbon atoms
- B – In the formation of acetyl-CoA from pyruvate
- C – During the transfer of the CH3- group from tetrahydrofolate coenzyme to homocysteine
- D – In the synthesis of palmitate
- All of the statements below regarding purine biosynthesis nucleotides are correct except:
- A – PRPP is a substrate in this metabolic pathway
- B – 2 nitrogen atoms of the purine cycle are formed from glutamine
- C – Formation of N-glycosidic bond only after completion of base structure
- D – Folate cofactors are involved in the carbons of the purine cycle
- E – Inosine monophosphate is a precursor to both AMP and GMP.
- Gout is caused by an excessive increase in the concentration of uric acid in the blood. The cause can be both overproduction and insufficient excretion. To recognize this situation, 15N-labeled amino acid can be administered. Which one is best for this purpose?
Case reports[edit | edit source]
Female patient treated for acute leukemia[edit | edit source]
A 3-year-old girl was admitted with a diagnosis of acute lymphocytic leukemia. She received IVs, allopurinol, 2nd day of vincristine therapy, prednisone, methotrexate, etc. Discharged home in 5 days. She continued therapy at home (prednisone, allopurinol). Added chemotherapy again in a month. Then she gotthrush in her mouth, she couldn't eat.
|S-uric acid||714||547||238||113||137||184 (μmol/l)|
|white blood cells||56,300||3,700||2,800||3,700 (count/ml of blood)|
- How do you explain the high uric acid level (1st examination performed after 5 days of hospitalization, after discharge)
- Why was the uric acid already normal during the next examinations?
- Why was there a urea level of 0.7 mmol/l?
- What other tests will confirm this finding?
Links[edit | edit source]
Related articles[edit | edit source]
Source[edit | edit source]
- MASOPUST, Jaroslav – PRŮŠA, Richard. Patobiochemie metabolických drah. 1. edition. Praha : Univerzita Karlova, 1999. 182 pp. pp. 113- 114. ISBN 80-238-4589-6.