Antidepressant intoxication
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== Antidepressants ==
- Frequent intoxication, these are substances that inhibit the reuptake of catecholamines and serotonin in the synapse, significant anticholinergic effects,
- representatives of TCAs (tricyclic antidepressants) – imipramine' (Melipramine®), amitryptiline', dosulepin' (Prothiaden®),
- have cardiotoxic manifestations - already at 10 times the therapeutic dose!
Clinical picture[edit | edit source]
- Poisoning TCA will cause an anticholinergic syndrome - dryness of the mucous membranes, mydriasis, tachycardia, slowing of the GIT, retention of urinee,
- impaired consciousness, convulsions,
- EKG – prolongation of the nitroventricular conduction (QRS widening), dysrhythmia (danger of ventricular fibrillation).
Therapy[edit | edit source]
- The antidote is not
- basis of treatment – high doses of activated charcoal, care of vital functions, symptomatic therapy.
Links[edit | edit source]
Related Articles[edit | edit source]
Source[edit | edit source]
- {{#switch: web
|book =
Incomplete publication citation. BENEŠ, GeorgeAlso available from <http://jirben.wz.cz>.
|collection =
Incomplete citation of contribution in proceedings. BENEŠ, George. Also available from <http://jirben.wz.cz>. {{ #if: |978-80-7262-438-6} } |article = Incomplete article citation. BENEŠ, George. Study Materials. also available from <http://jirben.wz.cz>.
|web =
BENEŠ, George. Study Materials [online]. [cit. 2010-02-24]. <http://jirben.wz.cz>.
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BENEŠ, George. Study Materials [CD/DVD]. [cit. 2010-02-24].
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Incomplete database citation. Study Materials [database]. [cit. 2010-02-24]. <http://jirben.wz.cz>.
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Incomplete citation of company literature. BENEŠ, George. Also available from <http://jirben.wz.cz>. legislative_document = Incomplete citation of legislative document. Also available from URL <http://jirben.wz.cz>.
References[edit | edit source]
- {{#switch: book
|book =
Incomplete publication citation. PELCLOVÁ, Daniela. Occupational diseases and intoxication. Prague : Karolinum, 2006. 207 s. 978-80-7262-438-6.
|collection =
Incomplete citation of contribution in proceedings. PELCLOVÁ, Daniela. Occupational diseases and intoxication. Prague : Karolinum, 2006. 207 s. {{ #if: 80-246-1183-X |978-80-7262-438-6} } |article = Incomplete article citation. PELCLOVÁ, Daniela. 2006, year 2006,
|web =
Incomplete site citation. PELCLOVÁ, Daniela. Karolinum, ©2006.
|cd =
Incomplete carrier citation. PELCLOVÁ, Daniela. Karolinum, ©2006.
|db =
Incomplete database citation. Karolinum, ©2006.
|corporate_literature =
PELCLOVÁ, Daniela. Occupational diseases and intoxication. Prague : Karolinum, 2006. 207 s. 978-80-7262-438-6} }