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Antimitochondrial antibodies (AMA) are a type of autoantibodies usually assessed to diagnose primary biliary choleangitis (PBC), although they are also present in other autoimmune disorders. A number of subtypes of these antibodies have been recognized, some of which are specific mainly for PBC.

List os AMA subtypes and attributed clinical significance[edit | edit source]

  • Anti-M1syphilis;
  • Anti-M2 – primary biliary choleangitis (pathognomic sign);
  • Anti-M3drug-induced lupus;
  • Anti-M4 – primary biliary choleangitis (worse prognosis);
  • Anti-M5 – primary and secondary antiphospholipid syndrome, collagenosis;
  • Anti-M6 – drug-induced hepatitis;
  • Anti-M7 – acute myocarditis, cardiomyopathy;
  • Anti-M8 – primary biliary choleangitis (worse prognosis);
  • Anti-M9 – primary biliary choleangitis (usually better prognosis).

Links[edit | edit source]

Reated articles[edit | edit source]

Literature[edit | edit source]

  • HLUBINKA, Miloslav – HUSA, Petr. Gastroenterologie a hepatologie : Antimitochondriální protilátky vyskytující se u nemocných s primární biliární cirhózou - cílové antigenní struktury a diagnostika [online]. [cit. 2013-05-06]. <>.