Antimitochondrial antibodies (AMA) are a type of autoantibodies usually assessed to diagnose primary biliary choleangitis (PBC), although they are also present in other autoimmune disorders. A number of subtypes of these antibodies have been recognized, some of which are specific mainly for PBC.
List os AMA subtypes and attributed clinical significance[edit | edit source]
- Anti-M1 – syphilis;
- Anti-M2 – primary biliary choleangitis (pathognomic sign);
- Anti-M3 – drug-induced lupus;
- Anti-M4 – primary biliary choleangitis (worse prognosis);
- Anti-M5 – primary and secondary antiphospholipid syndrome, collagenosis;
- Anti-M6 – drug-induced hepatitis;
- Anti-M7 – acute myocarditis, cardiomyopathy;
- Anti-M8 – primary biliary choleangitis (worse prognosis);
- Anti-M9 – primary biliary choleangitis (usually better prognosis).
Links[edit | edit source]
Reated articles[edit | edit source]
Literature[edit | edit source]
- HLUBINKA, Miloslav – HUSA, Petr. Gastroenterologie a hepatologie : Antimitochondriální protilátky vyskytující se u nemocných s primární biliární cirhózou - cílové antigenní struktury a diagnostika [online]. [cit. 2013-05-06]. <http://www.csgh.info/cs/intro>.