Refractory hypertension

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náhled|200px|Nespolupráce pacienta („non-compliance“) Refractory hypertension (synonym Resistant hypertension, RH) is defined as blood pressure exceeding 140/90 mmHg – despite long enough treatment with triple combinations of antihypertensives of different classes, one of which is a diuretic.

*Currently, the definitions of refractory and resistant hypertension are different: resistant hypertension resists combination therapy of three groups of antihypertensives, one of which is a diuretic, while refractory hypertension resists combination of even five different groups of antihypertensives.

Risks[edit | edit source]

Patients with refractory hypertension have a higher risk of (compared to compensated hypertension):

Causes[edit | edit source]

The causes of refractory hypertension include:

  • secondary hypertension (must be treated causally);
  • inadequate antihypertensive treatment (inappropriate combination of antihypertensive drugs, inappropriate dosage);
  • associated diseases;
  • concomitant use of nonsteroidal antirheumatic drugs;
  • patient non-cooperation (patient does not respect the recommended doses and / or intervals; refuses to influence an unhealthy lifestyle: smoking, alcohol, salt, physical activity).


Links[edit | edit source]

Resources[edit | edit source]

  • HOLAJ, Robert. Kardiologický kroužek. III. interní klinika VFN a 1. LF UK v Praze, 2009.

Reference[edit | edit source]

  1. LEDVINA, Miroslav, et al. Biochemie pro studující medicíny. 2. vydání. Praha : Karolinum, 2009. 548 s. s. 85-90. ISBN 978-80-246-1414-4.

Used literature[edit | edit source]

  • LEDVINA, Miroslav, et al. Biochemie pro studující medicíny. 2. vydání. Praha : Karolinum, 2009. 548 s. s. 85-90. ISBN 978-80-246-1414-4.
  • LEDVINA, Miroslav, et al. Biochemie pro studující medicíny. 2. vydání. Praha : Karolinum, 2009. 548 s. s. 85-90. ISBN 978-80-246-1414-4.