Pick's disease

Pick's disease (MRI)

It is a form of frontotemporal lobar dementia. It is manifested by significant behavorial disorders and prefrontal syndrome. In severe stages, cognitive disorders also appear. It is degenerative brain disease affecting mainly cortex. It is a selective atrophy of the frontal (→ mental changes) and temporal (→ deafness) lobes. In the microscopic picture, Pick bodies are visible in the neurons. It starts mainly in the period before old age (50s-60s), often occurs in families. At the beginning, there are no changes in cognitive functions, but disorders of personality and emotionality – the co-called moriatic mood (euphoria with inappropriate joking, hypersexuality, deviation, overeating, hyperphagia).

Links

References

• BENEŠ, Jiří. Studijní materiály [online]. [cit. 2009]. <http://jirben.wz.cz>.